Predictive Computational Modeling of the Mucosal Immune Responses during Helicobacter pylori Infection

Adria Carbo; Josep Bassaganya-Riera; Mireia Pedragosa; Monica Viladomiu; Madhav Marathe; Stephen Eubank; Katherine Wendelsdorf; Keith Bisset; Stefan Hoops; Xinwei Deng; Maksudul Alam; Barbara Kronsteiner; Yongguo Mei; Raquel Hontecillas

doi:10.1371/journal.pone.0073365

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Research Article

Predictive Computational Modeling of the Mucosal Immune Responses during Helicobacter pylori Infection

Adria Carbo,

Affiliations Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America, Center for Modeling Immunity to Enteric Pathogens Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America
⨯
Josep Bassaganya-Riera,

Affiliations Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America, Center for Modeling Immunity to Enteric Pathogens Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America, Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia, United States of America
⨯
Mireia Pedragosa,

Affiliations Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America, Center for Modeling Immunity to Enteric Pathogens Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America
⨯
Monica Viladomiu,

Affiliations Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America, Center for Modeling Immunity to Enteric Pathogens Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America
⨯
Madhav Marathe,

Affiliations Center for Modeling Immunity to Enteric Pathogens Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America, Network Dynamics and Simulation Science Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America
⨯
Stephen Eubank,

Affiliations Center for Modeling Immunity to Enteric Pathogens Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America, Network Dynamics and Simulation Science Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America
⨯
Katherine Wendelsdorf,

Affiliations Center for Modeling Immunity to Enteric Pathogens Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America, Network Dynamics and Simulation Science Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America
⨯
Keith Bisset,

Affiliations Center for Modeling Immunity to Enteric Pathogens Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America, Network Dynamics and Simulation Science Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America
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Stefan Hoops,

Affiliations Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America, Center for Modeling Immunity to Enteric Pathogens Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America
⨯
Xinwei Deng,

Affiliations Center for Modeling Immunity to Enteric Pathogens Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America, Department of Statistics, Virginia Tech, Blacksburg, Virginia, United States of America
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Maksudul Alam,

Affiliations Center for Modeling Immunity to Enteric Pathogens Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America, Network Dynamics and Simulation Science Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America
⨯
Barbara Kronsteiner,

Affiliations Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America, Center for Modeling Immunity to Enteric Pathogens Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America
⨯
Yongguo Mei,

Affiliations Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America, Center for Modeling Immunity to Enteric Pathogens Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America
⨯
Raquel Hontecillas

* E-mail: rmagarzo@vt.edu

Affiliations Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America, Center for Modeling Immunity to Enteric Pathogens Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America
⨯

Predictive Computational Modeling of the Mucosal Immune Responses during Helicobacter pylori Infection

Adria Carbo,
Josep Bassaganya-Riera,
Mireia Pedragosa,
Monica Viladomiu,
Madhav Marathe,
Stephen Eubank,
Katherine Wendelsdorf,
Keith Bisset,
Stefan Hoops,
Xinwei Deng

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Published: September 5, 2013
https://doi.org/10.1371/journal.pone.0073365

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Helicobacter pylori
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T cells
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Gastrointestinal infections
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Immune response
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Macrophages
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Helicobacter pylori infection
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Epithelial cells
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Regulatory T cells
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