Pomalidomide Shows Significant Therapeutic Activity against CNS Lymphoma with a Major Impact on the Tumor Microenvironment in Murine Models

Zhimin Li; Yushi Qiu; David Personett; Peng Huang; Brandy Edenfield; Jason Katz; Darius Babusis; Yang Tang; Michael A. Shirely; Mehran F. Moghaddam; John A. Copland; Han W. Tun

doi:10.1371/journal.pone.0071754

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Open Access

Peer-reviewed

Research Article

Pomalidomide Shows Significant Therapeutic Activity against CNS Lymphoma with a Major Impact on the Tumor Microenvironment in Murine Models

Zhimin Li,

Affiliation Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America
⨯
Yushi Qiu,

Affiliation Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America
⨯
David Personett,

Affiliation Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America
⨯
Peng Huang,

Affiliation Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America
⨯
Brandy Edenfield,

Affiliation Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America
⨯
Jason Katz,

Affiliation Department of Drug Metabolism and Pharmacokinetics, Celgene Corporation, San Diego, California, United States of America
⨯
Darius Babusis,

Affiliation Department of Drug Metabolism and Pharmacokinetics, Celgene Corporation, San Diego, California, United States of America
⨯
Yang Tang,

Affiliation Department of Drug Metabolism and Pharmacokinetics, Celgene Corporation, San Diego, California, United States of America
⨯
Michael A. Shirely,

Affiliation Department of Drug Metabolism and Pharmacokinetics, Celgene Corporation, San Diego, California, United States of America
⨯
Mehran F. Moghaddam,

Affiliation Department of Drug Metabolism and Pharmacokinetics, Celgene Corporation, San Diego, California, United States of America
⨯
John A. Copland,

Affiliation Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America
⨯
Han W. Tun

* E-mail: tun.han@mayo.edu

Affiliation Department of Hematology/Oncology, Mayo Clinic, Jacksonville, Florida, United States of America
⨯

Pomalidomide Shows Significant Therapeutic Activity against CNS Lymphoma with a Major Impact on the Tumor Microenvironment in Murine Models

Zhimin Li,
Yushi Qiu,
David Personett,
Peng Huang,
Brandy Edenfield,
Jason Katz,
Darius Babusis,
Yang Tang,
Michael A. Shirely,
Mehran F. Moghaddam

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Published: August 5, 2013
https://doi.org/10.1371/journal.pone.0071754

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Macrophages
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Central nervous system
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Lymphoma
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Neurological tumors
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