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Research Article

Lysine-Specific Demethylase 1 (LSD1/KDM1A) Contributes to Colorectal Tumorigenesis via Activation of the Wnt/Β-Catenin Pathway by Down-Regulating Dickkopf-1 (DKK1)

  • Zebin Huang,

    Affiliation: National Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing, China

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  • Shangze Li,

    Affiliation: Department of Cellular and Developmental Biology, College of Life Sciences, Wuhan University, Wuhan, China

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  • Wei Song,

    Affiliation: National Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing, China

    X
  • Xin Li,

    Affiliation: Department of Cellular and Developmental Biology, College of Life Sciences, Wuhan University, Wuhan, China

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  • Qinshan Li,

    Affiliation: National Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing, China

    X
  • Zeyan Zhang,

    Affiliation: Department of Cellular and Developmental Biology, College of Life Sciences, Wuhan University, Wuhan, China

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  • Yongqing Han,

    Affiliation: National Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing, China

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  • Xiaodong Zhang,

    Affiliation: Department of Cellular and Developmental Biology, College of Life Sciences, Wuhan University, Wuhan, China

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  • Shiying Miao,

    Affiliation: National Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing, China

    X
  • Runlei Du mail,

    runleidu@whu.edu.cn (RD); wang.linfang@imicams.ac.cn (LW)

    Affiliation: Department of Cellular and Developmental Biology, College of Life Sciences, Wuhan University, Wuhan, China

    X
  • Linfang Wang mail

    runleidu@whu.edu.cn (RD); wang.linfang@imicams.ac.cn (LW)

    Affiliation: National Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing, China

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  • Published: July 26, 2013
  • DOI: 10.1371/journal.pone.0070077

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