Primary Respiratory Chain Disease Causes Tissue-Specific Dysregulation of the Global Transcriptome and Nutrient-Sensing Signaling Network

• Zhe Zhang,

  Affiliation Center for Biomedical Informatics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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• Mai Tsukikawa,

  Affiliation Division of Human Genetics, Department of Pediatrics, The Children’s Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Min Peng,

  Affiliation Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Erzsebet Polyak,

  Affiliation Division of Human Genetics, Department of Pediatrics, The Children’s Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Eiko Nakamaru-Ogiso,

  Affiliation Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Julian Ostrovsky,

  Affiliation Division of Human Genetics, Department of Pediatrics, The Children’s Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Shana McCormack,

  Affiliation Division of Endocrinology, Department of Pediatrics, The Children’s Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Emily Place,

  Current address: Ocular Genomics Institute, Massachusetts Eye and Ear Infirmary (MEEI), Harvard Medical School, Boston, Massachusetts, United States of America

  Affiliation Division of Human Genetics, Department of Pediatrics, The Children’s Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Colleen Clarke,

  Affiliations Division of Human Genetics, Department of Pediatrics, The Children’s Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Division of Child Development and Metabolic Disease, The Children’s Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Gail Reiner,

  Affiliation Department of Pediatrics, University of California San Diego, San Diego, California, United States of America

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• Elizabeth McCormick,

  Affiliations Division of Human Genetics, Department of Pediatrics, The Children’s Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Division of Child Development and Metabolic Disease, The Children’s Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Eric Rappaport,

  Affiliation Nucleic Acid and Protein Core Facility, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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• Richard Haas,

  Affiliation Department of Pediatrics, University of California San Diego, San Diego, California, United States of America

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• Joseph A. Baur,

  Affiliation Department of Physiology, and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Marni J. Falk

  * E-mail: falkm@email.chop.edu

  Affiliations Division of Human Genetics, Department of Pediatrics, The Children’s Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Division of Child Development and Metabolic Disease, The Children’s Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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