Pharmacometabolomics of Response to Sertraline and to Placebo in Major Depressive Disorder – Possible Role for Methoxyindole Pathway

• Hongjie Zhu ,

  Contributed equally to this work with: Hongjie Zhu, Mikhail B. Bogdanov

  Affiliation Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, United States of America

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• Mikhail B. Bogdanov ,

  Contributed equally to this work with: Hongjie Zhu, Mikhail B. Bogdanov

  Affiliation Department of Neurology and Neuroscience Weill Cornell Medical College, New York, New York, United States of America

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• Stephen H. Boyle,

  Affiliation Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, United States of America

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• Wayne Matson,

  Affiliation Department of Systems Biochemistry, Bedford VA Medical Center, Bedford, Massachusetts, United States of America

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• Swati Sharma,

  Affiliation Department of Systems Biochemistry, Bedford VA Medical Center, Bedford, Massachusetts, United States of America

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• Samantha Matson,

  Affiliations Department of Systems Biochemistry, Bedford VA Medical Center, Bedford, Massachusetts, United States of America, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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• Erik Churchill,

  Affiliation Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, United States of America

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• Oliver Fiehn,

  Affiliation Genome Center, University of California Davis, Davis, California, United States of America

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• John A. Rush,

  Affiliation Duke-NUS Graduate Medical School, Singapore, Singapore

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• Ranga R. Krishnan,

  Affiliations Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, United States of America, Duke-NUS Graduate Medical School, Singapore, Singapore

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• Eve Pickering,

  Affiliation Pfizer Global R&D, Clinical Research Statistics, Groton, Connecticut, United States of America

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• Marielle Delnomdedieu,

  Affiliation Pfizer Global R&D, Neuroscience Clinical Research, Groton, Connecticut, United States of America

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• Rima Kaddurah-Daouk ,

  * E-mail: rima.kaddurahdaouk.duke.edu

  Affiliation Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, United States of America

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• Pharmacometabolomics Research Network