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Open Access

Peer-reviewed

Research Article

Optimizing Nasal Potential Difference Analysis for CFTR Modulator Development: Assessment of Ivacaftor in CF Subjects with the G551D-CFTR Mutation

  • Steven M. Rowe,

    Affiliation University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Bo Liu,

    Affiliation University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Aubrey Hill,

    Affiliation University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Heather Hathorne,

    Affiliation University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Morty Cohen,

    Current address: Morty Cohen Research Consulting, Seattle, Washington, United States of America

    Affiliation Seattle Children's Hospital, Seattle, Washington, United States of America

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  • John R. Beamer,

    Current address: ALK Source Materials, Inc., Post Falls, Idaho, United States of America

    Affiliation Seattle Children's Hospital, Seattle, Washington, United States of America

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  • Frank J. Accurso,

    Affiliation University of Colorado Denver, Aurora, Colorado, United States of America

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  • Qunming Dong,

    Affiliation Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts, United States of America

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  • Claudia L. Ordoñez,

    Current address: Biogen, Boston, Massachusetts, United States of America

    Affiliation Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts, United States of America

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  • Anne J. Stone,

    Affiliation Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts, United States of America

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  • Eric R. Olson,

    Affiliation Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts, United States of America

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  • John P. Clancy ,

    john.clancy@cchmc.org

    Affiliation Cincinnati Children's Hospital Medical Center and the University of Cincinnati, Cincinnati, Ohio, United States of America

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  • for the VX06-770-101 Study Group

    Membership of the VX06-770-101 Study Group is provided in the Acknowledgments.

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