Rapamycin Inhibits IGF-1-Mediated Up-Regulation of MDM2 and Sensitizes Cancer Cells to Chemotherapy

Wei Du; Yong Yi; Haibo Zhang; Johann Bergholz; Junfeng Wu; Haoqiang Ying; Yujun Zhang; Zhi-Xiong Jim Xiao

doi:10.1371/journal.pone.0063179

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Open Access

Peer-reviewed

Research Article

Rapamycin Inhibits IGF-1-Mediated Up-Regulation of MDM2 and Sensitizes Cancer Cells to Chemotherapy

Wei Du ,

Contributed equally to this work with: Wei Du, Yong Yi

Affiliation Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
Yong Yi ,

Contributed equally to this work with: Wei Du, Yong Yi

Affiliation Center of Growth, Metabolism and Aging, College of Life Sciences and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China
⨯
Haibo Zhang,

Affiliation Center of Growth, Metabolism and Aging, College of Life Sciences and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China
⨯
Johann Bergholz,

Affiliations Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, United States of America, Center of Growth, Metabolism and Aging, College of Life Sciences and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China
⨯
Junfeng Wu,

Affiliation Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
Haoqiang Ying,

Affiliation The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Yujun Zhang,

Affiliation Center of Growth, Metabolism and Aging, College of Life Sciences and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China
⨯
Zhi-Xiong Jim Xiao

* E-mail: jimzx@scu.edu.cn

Affiliations Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, United States of America, Center of Growth, Metabolism and Aging, College of Life Sciences and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China
⨯

Rapamycin Inhibits IGF-1-Mediated Up-Regulation of MDM2 and Sensitizes Cancer Cells to Chemotherapy

Wei Du,
Yong Yi,
Haibo Zhang,
Johann Bergholz,
Junfeng Wu,
Haoqiang Ying,
Yujun Zhang,
Zhi-Xiong Jim Xiao

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Published: April 30, 2013
https://doi.org/10.1371/journal.pone.0063179

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