SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians

• Akinori Miyashita ,

  Contributed equally to this work with: Akinori Miyashita, Asako Koike, Gyungah Jun

  Affiliation Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan

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• Asako Koike ,

  Contributed equally to this work with: Akinori Miyashita, Asako Koike, Gyungah Jun

  Affiliation Central Research Laboratory, Hitachi Ltd, Tokyo, Japan

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• Gyungah Jun ,

  Contributed equally to this work with: Akinori Miyashita, Asako Koike, Gyungah Jun

  Affiliation Departments of Medicine (Biomedical Genetics), Ophthalmology and Biostatistics, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America

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• Li-San Wang,

  Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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• Satoshi Takahashi †,

  † Deceased.

  Affiliation Department of Neurology, Iwate Medical University, Morioka, Japan

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• Etsuro Matsubara,

  Affiliation Department of Neurology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan

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• Takeshi Kawarabayashi,

  Affiliation Department of Neurology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan

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• Mikio Shoji,

  Affiliation Department of Neurology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan

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• Naoki Tomita,

  Affiliation Department of Geriatric and Complementary Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan

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• Hiroyuki Arai,

  Affiliation Department of Geriatric and Complementary Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan

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• Takashi Asada,

  Affiliation Department of Psychiatry, University of Tsukuba, Tsukuba, Japan

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• Yasuo Harigaya,

  Affiliation Department of Neurology, Maebashi Red Cross Hospital, Maebashi, Japan

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• Masaki Ikeda,

  Affiliation Department of Neurology, Gunma University Graduate School of Medicine, Maebashi, Japan

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• Masakuni Amari,

  Affiliation Department of Neurology, Gunma University Graduate School of Medicine, Maebashi, Japan

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• Haruo Hanyu,

  Affiliation Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan

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• Susumu Higuchi,

  Affiliation Division of Clinical Research, Kurihama Alcoholism Center, Yokosuka, Japan

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• Takeshi Ikeuchi,

  Affiliation Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan

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• Masatoyo Nishizawa,

  Affiliation Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan

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• Masaichi Suga,

  Affiliation Higashi Niigata Hospital, Niigata, Japan

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• Yasuhiro Kawase,

  Affiliation Kawase Neurology Clinic, Sanjo, Japan

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• Hiroyasu Akatsu,

  Affiliation Choju Medical Institute, Fukushimura Hospital, Toyohashi, Japan

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• Kenji Kosaka,

  Affiliation Choju Medical Institute, Fukushimura Hospital, Toyohashi, Japan

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• Takayuki Yamamoto,

  Affiliation Choju Medical Institute, Fukushimura Hospital, Toyohashi, Japan

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• Masaki Imagawa,

  Affiliation Imagawa Clinic, Osaka, Japan

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• Tsuyoshi Hamaguchi,

  Affiliation Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan

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• Masahito Yamada,

  Affiliation Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan

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• Takashi Moriaha,

  Affiliation Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan

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• Masatoshi Takeda,

  Affiliation Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan

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• Takeo Takao,

  Affiliation Kurashiki Heisei Hospital, Kurashiki, Japan

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• Kenji Nakata,

  Affiliation Kinoko Espoir Hospital, Kasaoka, Japan

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• Yoshikatsu Fujisawa †,

  † Deceased.

  Affiliation Kinoko Espoir Hospital, Kasaoka, Japan

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• Ken Sasaki,

  Affiliation Kinoko Espoir Hospital, Kasaoka, Japan

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• Ken Watanabe,

  Affiliation Watanabe Hospital, Tottori, Japan

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• Kenji Nakashima,

  Affiliation Department of Neurology Tottori University, Yonago, Japan

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• Katsuya Urakami,

  Affiliation Department of Biological Regulation, Section of Environment and Health Science, Tottori University, Yonago, Japan

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• Terumi Ooya,

  Affiliation Town Office, Onan, Japan

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• Mitsuo Takahashi,

  Affiliation Department of Clinical Pharmacology, Fukuoka University, Fukuoka, Japan

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• Takefumi Yuzuriha,

  Affiliation Department of Psychiatry, National Hospital Organization, Hizen Psychiatric Center, Saga, Japan

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• Kayoko Serikawa,

  Affiliation Ureshino-Onsen Hospital, Saga, Japan

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• Seishi Yoshimoto,

  Affiliation Ureshino-Onsen Hospital, Saga, Japan

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• Ryuji Nakagawa,

  Affiliation Ureshino-Onsen Hospital, Saga, Japan

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• Jong-Won Kim,

  Affiliation Department of Laboratory Medicine & Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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• Chang-Seok Ki,

  Affiliation Department of Laboratory Medicine & Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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• Hong-Hee Won,

  Affiliation Department of Laboratory Medicine & Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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• Duk L. Na,

  Affiliation Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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• Sang Won Seo,

  Affiliation Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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• Inhee Mook-Jung,

  Affiliation Department of Biochemistry & Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea

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• The Alzheimer Disease Genetics Consortium ,

  ¶‡ Membership of The Alzheimer Disease Genetics Consortium is provided in the Acknowledgments.

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• Peter St. George-Hyslop,

  Affiliation Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada, and the Department of Clinical Neurosciences, Cambridge Institute for Medical Research, Cambridge, United Kingdom

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• Richard Mayeux,

  Affiliation Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, United States of America

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• Jonathan L. Haines,

  Affiliation Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America

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• Margaret A. Pericak-Vance,

  Affiliation The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America

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• Makiko Yoshida,

  Affiliation Central Research Laboratory, Hitachi Ltd, Tokyo, Japan

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• Nao Nishida,

  Affiliation Department of Human Genetics, University of Tokyo, Tokyo, Japan

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• Katsushi Tokunaga,

  Affiliation Department of Human Genetics, University of Tokyo, Tokyo, Japan

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• Ken Yamamoto,

  Affiliation Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan

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• Shoji Tsuji,

  Affiliation Department of Neurology, University of Tokyo, Tokyo, Japan

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• Ichiro Kanazawa,

  Affiliation National Center for Neurology and Psychiatry, Kodaira, Japan

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• Yasuo Ihara,

  Affiliation Department of Neuropathology, Doshisha University, Kyoto, Japan

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• Gerard D. Schellenberg,

  Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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• Lindsay A. Farrer ,

  * E-mail: ryosun@bri.niigata-u.ac.jp (RK); farrer@bu.edu (LAF)

  ¶These authors also contributed equally to this work.

  Affiliations Departments of Medicine (Biomedical Genetics), Ophthalmology and Biostatistics, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Departments of Neurology, Ophthalmology, Genetics & Genomics, and Epidemiology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America

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•  [ ... ],
• Ryozo Kuwano

  * E-mail: ryosun@bri.niigata-u.ac.jp (RK); farrer@bu.edu (LAF)

  ¶These authors also contributed equally to this work.

  Affiliation Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan

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