Efficient Methods for Targeted Mutagenesis in Zebrafish Using Zinc-Finger Nucleases: Data from Targeting of Nine Genes Using CompoZr or CoDA ZFNs

Raman Sood; Blake Carrington; Kevin Bishop; MaryPat Jones; Alberto Rissone; Fabio Candotti; Settara C. Chandrasekharappa; Paul Liu

doi:10.1371/journal.pone.0057239

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Open Access

Peer-reviewed

Research Article

Efficient Methods for Targeted Mutagenesis in Zebrafish Using Zinc-Finger Nucleases: Data from Targeting of Nine Genes Using CompoZr or CoDA ZFNs

Raman Sood ,

* E-mail: rsood@mail.nih.gov

Affiliation Zebrafish Core Facility, Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America
⨯
Blake Carrington ,

Contributed equally to this work with: Blake Carrington, Kevin Bishop

Affiliation Zebrafish Core Facility, Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America
⨯
Kevin Bishop ,

Contributed equally to this work with: Blake Carrington, Kevin Bishop

Affiliation Zebrafish Core Facility, Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America
⨯
MaryPat Jones,

Affiliation Genomics Core, Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America
⨯
Alberto Rissone,

Affiliation Disorders in Immunity Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America
⨯
Fabio Candotti,

Affiliation Disorders in Immunity Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America
⨯
Settara C. Chandrasekharappa,

Affiliation Genomics Core, Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America
⨯
Paul Liu

Affiliation Oncogenesis and Development Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America
⨯

Efficient Methods for Targeted Mutagenesis in Zebrafish Using Zinc-Finger Nucleases: Data from Targeting of Nine Genes Using CompoZr or CoDA ZFNs

Raman Sood,
Blake Carrington,
Kevin Bishop,
MaryPat Jones,
Alberto Rissone,
Fabio Candotti,
Settara C. Chandrasekharappa,
Paul Liu

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Published: February 22, 2013
https://doi.org/10.1371/journal.pone.0057239

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Zebrafish
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Polymerase chain reaction
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Zinc finger nucleases
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Insertion mutation
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Mutation detection
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Heterozygosity
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DNA extraction
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Gene pool
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