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Open Access

Peer-reviewed

Research Article

Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism

  • Sebastiano Collino ,

    sebastiano.collino@rd.nestle.com

    Affiliation Proteomics and Metabonomics, Nestlé Institute of Health Sciences SA, Campus EPFL, Quartier de l'innovation, Lausanne, Switzerland

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  • Ivan Montoliu,

    Affiliation Applied Mathematics, NESTEC SA, Nestlé Research Center, Lausanne, Switzerland

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  • François-Pierre J. Martin,

    Affiliation Proteomics and Metabonomics, Nestlé Institute of Health Sciences SA, Campus EPFL, Quartier de l'innovation, Lausanne, Switzerland

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  • Max Scherer,

    Affiliation Proteomics and Metabonomics, Nestlé Institute of Health Sciences SA, Campus EPFL, Quartier de l'innovation, Lausanne, Switzerland

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  • Daniela Mari,

    Affiliations Department of Medical Sciences, University of Milan, Milan, Italy, Geriatric Unit Ca' Grande Foundation Maggiore Policlinico Hospital, Milan, Italy

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  • Stefano Salvioli,

    Affiliations Department of Experimental Pathology, University of Bologna, Bologna, Italy, Interdepartmental Centre L. Galvani, University of Bologna, Bologna, Italy

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  • Laura Bucci,

    Affiliations Department of Experimental Pathology, University of Bologna, Bologna, Italy, Interdepartmental Centre L. Galvani, University of Bologna, Bologna, Italy

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  • Rita Ostan,

    Affiliations Department of Experimental Pathology, University of Bologna, Bologna, Italy, Interdepartmental Centre L. Galvani, University of Bologna, Bologna, Italy

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  • Daniela Monti,

    Affiliation Department of Experimental Pathology and Oncology, University of Florence, Florence, Italy

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  • Elena Biagi,

    Affiliation Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy

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  • Patrizia Brigidi,

    Affiliation Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy

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  • Claudio Franceschi,

    Affiliations Department of Experimental Pathology, University of Bologna, Bologna, Italy, Interdepartmental Centre L. Galvani, University of Bologna, Bologna, Italy

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  • Serge Rezzi

    Affiliation Proteomics and Metabonomics, Nestlé Institute of Health Sciences SA, Campus EPFL, Quartier de l'innovation, Lausanne, Switzerland

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