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The Presence of Methylation Quantitative Trait Loci Indicates a Direct Genetic Influence on the Level of DNA Methylation in Adipose Tissue

  • Alexander W. Drong,

    Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

  • George Nicholson,

    Affiliation Department of Statistics, University of Oxford, Oxford, United Kingdom

  • Åsa K. Hedman,

    Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

  • Eshwar Meduri,

    Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom

  • Elin Grundberg,

    Affiliations Wellcome Trust Sanger Institute, Hinxton, United Kingdom, Department of Twin Research, King's College London, London, United Kingdom

  • Kerrin S. Small,

    Affiliation Department of Twin Research, King's College London, London, United Kingdom

  • So-Youn Shin,

    Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom

  • Jordana T. Bell,

    Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Department of Twin Research, King's College London, London, United Kingdom

  • Fredrik Karpe,

    Affiliation Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom

  • Nicole Soranzo,

    Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom

  • Tim D. Spector,

    Affiliation Department of Twin Research, King's College London, London, United Kingdom

  • Mark I. McCarthy,

    Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom

  • Panos Deloukas,

    Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom

  • Mattias Rantalainen ,

    Contributed equally to this work with: Mattias Rantalainen, Cecilia M. Lindgren

    Affiliation Department of Statistics, University of Oxford, Oxford, United Kingdom

  • Cecilia M. Lindgren ,

    Contributed equally to this work with: Mattias Rantalainen, Cecilia M. Lindgren

    celi@well.ox.ac.uk

    Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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