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Research Article

Peripheral Nerve Injury Is Associated with Chronic, Reversible Changes in Global DNA Methylation in the Mouse Prefrontal Cortex

  • Maral Tajerian equal contributor,

    equal contributor Contributed equally to this work with: Maral Tajerian, Sebastian Alvarado

    Affiliations: Alan Edwards Centre for Research on Pain, Faculty of Medicine, McGill University, Montreal, Canada, Department of Neurology and Neurosurgery, McGill University, Montreal, Canada

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  • Sebastian Alvarado equal contributor,

    equal contributor Contributed equally to this work with: Maral Tajerian, Sebastian Alvarado

    Affiliations: Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada, Sackler Program for Epigenetics and Psychobiology, McGill University, Montreal, Canada

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  • Magali Millecamps,

    Affiliations: Alan Edwards Centre for Research on Pain, Faculty of Medicine, McGill University, Montreal, Canada, Faculty of Dentistry, McGill University, Montreal, Quebec, Canada

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  • Pascal Vachon,

    Affiliation: University of Montreal, Department of Veterinary Biomedicine, St-Hyacinthe, Quebec, Canada

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  • Cecilia Crosby,

    Affiliations: Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada, Sackler Program for Epigenetics and Psychobiology, McGill University, Montreal, Canada

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  • M. Catherine Bushnell,

    Affiliations: Alan Edwards Centre for Research on Pain, Faculty of Medicine, McGill University, Montreal, Canada, Department of Anesthesiology, McGill University, Montreal, Canada, Department of Neurology and Neurosurgery, McGill University, Montreal, Canada, Faculty of Dentistry, McGill University, Montreal, Quebec, Canada

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  • Moshe Szyf mail,

    moshe.szyf@mcgill.ca (MS); laura.s.stone@mcgill.ca (LS)

    Affiliations: Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada, Sackler Program for Epigenetics and Psychobiology, McGill University, Montreal, Canada

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  • Laura S. Stone mail

    moshe.szyf@mcgill.ca (MS); laura.s.stone@mcgill.ca (LS)

    Affiliations: Alan Edwards Centre for Research on Pain, Faculty of Medicine, McGill University, Montreal, Canada, Department of Anesthesiology, McGill University, Montreal, Canada, Department of Neurology and Neurosurgery, McGill University, Montreal, Canada, Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada, Faculty of Dentistry, McGill University, Montreal, Quebec, Canada

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  • Published: January 28, 2013
  • DOI: 10.1371/journal.pone.0055259

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