Genetic and Pharmacological Targeting of CSF-1/CSF-1R Inhibits Tumor-Associated Macrophages and Impairs BRAF-Induced Thyroid Cancer Progression

Mabel Ryder; Matti Gild; Tobias M. Hohl; Eric Pamer; Jeff Knauf; Ronald Ghossein; Johanna A. Joyce; James A. Fagin

doi:10.1371/journal.pone.0054302

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Peer-reviewed

Research Article

Genetic and Pharmacological Targeting of CSF-1/CSF-1R Inhibits Tumor-Associated Macrophages and Impairs BRAF-Induced Thyroid Cancer Progression

Mabel Ryder,

Affiliations Human Oncology and Pathogenesis Program, Memorial-Sloan-Kettering Cancer Center, New York, New York, United States of America, Department of Medicine, Memorial-Sloan-Kettering Cancer Center, New York, New York, United States of America
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Matti Gild,

Affiliation Human Oncology and Pathogenesis Program, Memorial-Sloan-Kettering Cancer Center, New York, New York, United States of America
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Tobias M. Hohl,

Affiliations Department of Medicine, Memorial-Sloan-Kettering Cancer Center, New York, New York, United States of America, Department of Infectious Diseases Service & Immunology Program, Memorial-Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯
Eric Pamer,

Affiliations Department of Medicine, Memorial-Sloan-Kettering Cancer Center, New York, New York, United States of America, Department of Infectious Diseases Service & Immunology Program, Memorial-Sloan-Kettering Cancer Center, New York, New York, United States of America
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Jeff Knauf,

Affiliation Human Oncology and Pathogenesis Program, Memorial-Sloan-Kettering Cancer Center, New York, New York, United States of America
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Ronald Ghossein,

Affiliation Department of Pathology, Memorial-Sloan-Kettering Cancer Center, New York, New York, United States of America
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Johanna A. Joyce,

Affiliation Department of Cancer Biology & Genetics, Memorial-Sloan-Kettering Cancer Center, New York, New York, United States of America
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James A. Fagin

* E-mail: faginj@mkscc.org

Affiliations Human Oncology and Pathogenesis Program, Memorial-Sloan-Kettering Cancer Center, New York, New York, United States of America, Department of Medicine, Memorial-Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯

Genetic and Pharmacological Targeting of CSF-1/CSF-1R Inhibits Tumor-Associated Macrophages and Impairs BRAF-Induced Thyroid Cancer Progression

Mabel Ryder,
Matti Gild,
Tobias M. Hohl,
Eric Pamer,
Jeff Knauf,
Ronald Ghossein,
Johanna A. Joyce,
James A. Fagin

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Published: January 23, 2013
https://doi.org/10.1371/journal.pone.0054302

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