Insights into the Genetic Architecture of Early Stage Age-Related Macular Degeneration: A Genome-Wide Association Study Meta-Analysis

• Elizabeth G. Holliday ,

  Contributed equally to this work with: Elizabeth G. Holliday, Albert V. Smith, Belinda K. Cornes, Gabriëlle H. S. Buitendijk, Richard A. Jensen, Xueling Sim

  * E-mail: Liz.Holliday@newcastle.edu.au

  Affiliation Centre for Clinical Epidemiology and Biostatistics, and School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia

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• Albert V. Smith ,

  Contributed equally to this work with: Elizabeth G. Holliday, Albert V. Smith, Belinda K. Cornes, Gabriëlle H. S. Buitendijk, Richard A. Jensen, Xueling Sim

  Affiliations Icelandic Heart Association, Kopavogur, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

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• Belinda K. Cornes ,

  Contributed equally to this work with: Elizabeth G. Holliday, Albert V. Smith, Belinda K. Cornes, Gabriëlle H. S. Buitendijk, Richard A. Jensen, Xueling Sim

  Affiliation Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore

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• Gabriëlle H. S. Buitendijk ,

  Contributed equally to this work with: Elizabeth G. Holliday, Albert V. Smith, Belinda K. Cornes, Gabriëlle H. S. Buitendijk, Richard A. Jensen, Xueling Sim

  Affiliations Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

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• Richard A. Jensen ,

  Contributed equally to this work with: Elizabeth G. Holliday, Albert V. Smith, Belinda K. Cornes, Gabriëlle H. S. Buitendijk, Richard A. Jensen, Xueling Sim

  Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America

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• Xueling Sim ,

  Contributed equally to this work with: Elizabeth G. Holliday, Albert V. Smith, Belinda K. Cornes, Gabriëlle H. S. Buitendijk, Richard A. Jensen, Xueling Sim

  Affiliations Centre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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• Thor Aspelund,

  Affiliations Icelandic Heart Association, Kopavogur, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

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• Tin Aung,

  Affiliation Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore

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• Paul N. Baird,

  Affiliation Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia

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• Eric Boerwinkle,

  Affiliation Human Genetics Center and Human Genome Sequencing Center, University of Texas and Baylor College of Medicine, Houston, Texas, United States of America

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• Ching Yu Cheng,

  Affiliations Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore, Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore, Singapore

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• Cornelia M. van Duijn,

  Affiliation Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

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• Gudny Eiriksdottir,

  Affiliation Icelandic Heart Association, Kopavogur, Iceland

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• Vilmundur Gudnason,

  Affiliations Icelandic Heart Association, Kopavogur, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

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• Tamara Harris,

  Affiliation Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, United States of America

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• Alex W. Hewitt,

  Affiliation Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia

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• Michael Inouye,

  Affiliation Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia

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• Fridbert Jonasson,

  Affiliations Faculty of Medicine, University of Iceland, Reykjavik, Iceland, Department of Ophthalmology, Landspitali University Hospital, Reykjavik, Iceland

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• Barbara E. K. Klein,

  Affiliation Department of Ophthalmology and Visual Science, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America

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• Lenore Launer,

  Affiliation Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, United States of America

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• Xiaohui Li,

  Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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• Gerald Liew,

  Affiliation Centre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, University of Sydney, Sydney, Australia

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• Thomas Lumley,

  Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Statistics, University of Auckland, Auckland, New Zealand

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• Patrick McElduff,

  Affiliation Centre for Clinical Epidemiology and Biostatistics, and School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia

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• Barbara McKnight,

  Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

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• Paul Mitchell,

  Affiliation Centre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, University of Sydney, Sydney, Australia

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• Bruce M. Psaty,

  Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Department of Health Services, University of Washington, Seattle, Washington, United States of America, Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America

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• Elena Rochtchina,

  Affiliation Centre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, University of Sydney, Sydney, Australia

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• Jerome I. Rotter,

  Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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• Rodney J. Scott,

  Affiliation School of Biomedical Sciences, University of Newcastle, Newcastle, New South Wales, Australia and Hunter Medical Research Institute, and Hunter Area Pathology Service, Newcastle, New South Wales, Australia

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• Wanting Tay,

  Affiliation Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore

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• Kent Taylor,

  Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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• Yik Ying Teo,

  Affiliation Department of Epidemiology and Public Health, National University of Singapore, Singapore, Singapore

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• André G. Uitterlinden,

  Affiliations Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Clinical Chemistry, Erasmus Medical Center, Rotterdam, The Netherlands

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• Ananth Viswanathan,

  Affiliation Moorfields Eye Hospital, London, United Kingdom

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• Sophia Xie,

  Affiliation Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia

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• Wellcome Trust Case Control Consortium 2 ,

  ¶‡ Membership of the Wellcome Trust Case Control Consortium 2 is listed in Table S3 in File S2.

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• Johannes R. Vingerling ,

  ¶These authors also contributed equally to this work.

  Affiliations Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

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• Caroline C. W. Klaver ,

  ¶These authors also contributed equally to this work.

  Affiliations Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

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• E. Shyong Tai ,

  ¶These authors also contributed equally to this work.

  Affiliations Department of Epidemiology and Public Health, National University of Singapore, Singapore, Singapore, Department of Medicine, National University of Singapore, Singapore, Singapore, Duke-National University of Singapore Graduate Medical School, Singapore, Singapore

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• David Siscovick ,

  ¶These authors also contributed equally to this work.

  Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

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• Ronald Klein ,

  ¶These authors also contributed equally to this work.

  Affiliation Department of Ophthalmology and Visual Science, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America

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• Mary Frances Cotch ,

  ¶These authors also contributed equally to this work.

  Affiliation Division of Epidemiology and Clinical Applications, National Eye Institute, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, United States of America

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• Tien Y. Wong ,

  ¶These authors also contributed equally to this work.

  Affiliations Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia, Department of Ophthalmology, National University of Singapore, Singapore, Singapore

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• John Attia ,

  ¶These authors also contributed equally to this work.

  Affiliations Centre for Clinical Epidemiology and Biostatistics, and School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia, Department of Medicine, John Hunter Hospital and Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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•  [ ... ],
• Jie Jin Wang

  ¶These authors also contributed equally to this work.

  Affiliations Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia, Centre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, University of Sydney, Sydney, Australia

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