Combination of a Proteomics Approach and Reengineering of Meso Scale Network Models for Prediction of Mode-of-Action for Tyrosine Kinase Inhibitors

• Stefan Balabanov,

  Affiliations Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum (UCCH), University Hospital Eppendorf (UKE), Hamburg, Germany, Division of Hematology, University Hospital Zürich, Zürich, Switzerland

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• Thomas Wilhelm,

  Affiliations Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum (UCCH), University Hospital Eppendorf (UKE), Hamburg, Germany, Department of Biochemistry, University Hospital Aachen (UKA) of the Rheinisch.-Westfälische Technische Hochschule Aachen, Aachen, Germany

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• Simone Venz,

  Affiliations Department of Medical Biochemistry and Molecular Biology, University of Greifswald, Greifswald, Germany, Interfacultary Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany

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• Gunhild Keller,

  Affiliation Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum (UCCH), University Hospital Eppendorf (UKE), Hamburg, Germany

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• Christian Scharf,

  Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, University of Greifswald, Greifswald, Germany

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• Heike Pospisil,

  Affiliation Bioinformatics, University of Applied Sciences Wildau, Wildau, Germany

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• Melanie Braig,

  Affiliation Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum (UCCH), University Hospital Eppendorf (UKE), Hamburg, Germany

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• Christine Barett,

  Affiliation Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum (UCCH), University Hospital Eppendorf (UKE), Hamburg, Germany

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• Carsten Bokemeyer,

  Affiliation Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum (UCCH), University Hospital Eppendorf (UKE), Hamburg, Germany

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• Reinhard Walther,

  Affiliation Department of Medical Biochemistry and Molecular Biology, University of Greifswald, Greifswald, Germany

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• Tim H. Brümmendorf ,

  Contributed equally to this work with: Tim H. Brümmendorf, Andreas Schuppert

  Affiliations Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum (UCCH), University Hospital Eppendorf (UKE), Hamburg, Germany, Medizinische Klinik IV - Hämatologie und Onkologie, Universitätsklinikum Aachen (UKA) of the Rheinisch.-Westfälische Technische Hochschule Aachen, Aachen, Germany

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• Andreas Schuppert

  Contributed equally to this work with: Tim H. Brümmendorf, Andreas Schuppert

  * E-mail: schuppert@aices.rwth-aachen.de

  Affiliation Aachen Institute for Advanced Study in Computational Engineering Science (AICES), RWTH Aachen University, Aachen, Germany

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