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Research Article

Discriminating Survival Outcomes in Patients with Glioblastoma Using a Simulation-Based, Patient-Specific Response Metric

  • Maxwell Lewis Neal mail,

    mneal@uw.edu (MLN); Kristin.swanson@northwestern.edu (KRS)

    Affiliation: Department of Pathology, University of Washington, Seattle, Washington, United States of America

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  • Andrew D. Trister,

    Affiliation: Department of Radiation Oncology, University of Washington, Seattle, Washington, United States of America

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  • Tyler Cloke,

    Affiliation: Department of Pathology, University of Washington, Seattle, Washington, United States of America

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  • Rita Sodt,

    Affiliation: Department of Pathology, University of Washington, Seattle, Washington, United States of America

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  • Sunyoung Ahn,

    Affiliation: Department of Pathology, University of Washington, Seattle, Washington, United States of America

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  • Anne L. Baldock,

    Affiliations: Department of Pathology, University of Washington, Seattle, Washington, United States of America, Department of Neurological Surgery, Northwestern University, Chicago, Illinois, United States of America, Northwestern Brain Tumor Institute, Chicago, Illinois, United States of America

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  • Carly A. Bridge,

    Affiliations: Department of Pathology, University of Washington, Seattle, Washington, United States of America, Department of Neurological Surgery, Northwestern University, Chicago, Illinois, United States of America, Northwestern Brain Tumor Institute, Chicago, Illinois, United States of America

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  • Albert Lai,

    Affiliation: Department of Neurology, University of California Los Angeles, Los Angeles, California, United States of America

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  • Timothy F. Cloughesy,

    Affiliation: Department of Neurology, University of California Los Angeles, Los Angeles, California, United States of America

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  • Maciej M. Mrugala,

    Affiliation: Department of Neurology, University of Washington, Seattle, Washington, United States of America

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  • Jason K. Rockhill,

    Affiliation: Department of Radiation Oncology, University of Washington, Seattle, Washington, United States of America

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  • Russell C. Rockne,

    Affiliations: Department of Pathology, University of Washington, Seattle, Washington, United States of America, Department of Neurological Surgery, Northwestern University, Chicago, Illinois, United States of America, Northwestern Brain Tumor Institute, Chicago, Illinois, United States of America

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  • Kristin R. Swanson mail

    mneal@uw.edu (MLN); Kristin.swanson@northwestern.edu (KRS)

    Affiliations: Department of Pathology, University of Washington, Seattle, Washington, United States of America, Department of Neurological Surgery, Northwestern University, Chicago, Illinois, United States of America, Northwestern Brain Tumor Institute, Chicago, Illinois, United States of America, Department of Applied Mathematics, University of Washington, Seattle, Washington, United States of America, Nancy and Buster Alvord Brain Tumor Center, University of Washington, Seattle, Washington, United States of America

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  • Published: January 23, 2013
  • DOI: 10.1371/journal.pone.0051951

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