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Research Article

Local Administration of Soluble CD40:Fc to the Salivary Glands of Non-Obese Diabetic Mice Does Not Ameliorate Autoimmune Inflammation

  • Nienke Roescher,

    Affiliations: Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America, Division of Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands

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  • Jelle L. Vosters,

    Affiliations: Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America, Division of Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands

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  • Zhenan Lai,

    Affiliation: Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Toshimitsu Uede,

    Affiliation: Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan

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  • Paul P. Tak,

    Affiliations: Division of Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands, GlaxoSmithKline, London, United Kingdom

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  • John A. Chiorini mail

    jchiorini@dir.nidcr.nih.gov

    Affiliation: Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: December 26, 2012
  • DOI: 10.1371/journal.pone.0051375

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