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Research Article

CK2-Mediated Hyperphosphorylation of Topoisomerase I Targets Serine 506, Enhances Topoisomerase I–DNA Binding, and Increases Cellular Camptothecin Sensitivity

  • Keya Bandyopadhyay,

    Affiliation: Torrey Pines Institute for Molecular Studies, San Diego, California, United States of America

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  • Pingchuan Li,

    Affiliation: Torrey Pines Institute for Molecular Studies, San Diego, California, United States of America

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  • Ruth A. Gjerset mail

    rgjerset@tpims.org

    Affiliation: Torrey Pines Institute for Molecular Studies, San Diego, California, United States of America

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  • Published: November 21, 2012
  • DOI: 10.1371/journal.pone.0050427

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