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Research Article

Identification of Novel Translational Urinary Biomarkers for Acetaminophen-Induced Acute Liver Injury Using Proteomic Profiling in Mice

  • Rachel P. L. van Swelm,

    Affiliation: Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Coby M. M. Laarakkers,

    Affiliation: Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Ellen C. van der Kuur,

    Affiliation: Streekziekenhuis Koningin Beatrix Ziekenhuis, Winterswijk, The Netherlands

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  • Eva Morava-Kozicz,

    Affiliation: Department of Pediatrics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Ron A. Wevers,

    Affiliation: Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Kevin D. Augustijn,

    Affiliation: Department of Chemistry and Pharmacochemistry, Vrije Universiteit, Amsterdam, The Netherlands

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  • Daan J. Touw,

    Affiliation: Apotheek Haagse Ziekenhuizen, The Netherlands

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  • Maro H. Sandel,

    Affiliation: Hagaziekenhuis, Den Haag, The Netherlands

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  • Rosalinde Masereeuw,

    Affiliation: Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Frans G. M. Russel mail

    F.Russel@pharmtox.umcn.nl

    Affiliation: Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Published: November 14, 2012
  • DOI: 10.1371/journal.pone.0049524

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