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Imaging Mass Spectrometry Visualizes Ceramides and the Pathogenesis of Dorfman-Chanarin Syndrome Due to Ceramide Metabolic Abnormality in the Skin

  • Naoko Goto-Inoue,

    Affiliation Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka, Japan

  • Takahiro Hayasaka,

    Affiliation Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka, Japan

  • Nobuhiro Zaima,

    Affiliation Department of Applied Biological Chemistry, Kinki University, Nara, Nara, Japan

  • Kimiko Nakajima,

    Affiliation Department of Dermatology, Kochi Medical School, Kochi University, Kohasu, Okocho, Nankoku, Nankoku, Japan

  • Walter M. Holleran,

    Affiliation Department of Dermatology, School of Medicine, University of California San Francisco, Department of Veterans Affairs Medical Center, and Northern California Institute for Research and Education, San Francisco, California, United States of America

  • Shigetoshi Sano,

    Affiliation Department of Dermatology, Kochi Medical School, Kochi University, Kohasu, Okocho, Nankoku, Nankoku, Japan

  • Yoshikazu Uchida ,

    Contributed equally to this work with: Yoshikazu Uchida, Mitsutoshi Setou

    uchiday@derm.ucsf.edu (YU); setou@hama-med.ac.jp (MS)

    Affiliation Department of Dermatology, School of Medicine, University of California San Francisco, Department of Veterans Affairs Medical Center, and Northern California Institute for Research and Education, San Francisco, California, United States of America

  • Mitsutoshi Setou

    Contributed equally to this work with: Yoshikazu Uchida, Mitsutoshi Setou

    uchiday@derm.ucsf.edu (YU); setou@hama-med.ac.jp (MS)

    Affiliation Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka, Japan

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