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Research Article

Deletion of CDKAL1 Affects High-Fat Diet–Induced Fat Accumulation and Glucose-Stimulated Insulin Secretion in Mice, Indicating Relevance to Diabetes

  • Tadashi Okamura equal contributor,

    equal contributor Contributed equally to this work with: Tadashi Okamura, Rieko Yanobu-Takanashi

    Affiliation: Division of Animal Model, Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

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  • Rieko Yanobu-Takanashi equal contributor,

    equal contributor Contributed equally to this work with: Tadashi Okamura, Rieko Yanobu-Takanashi

    Affiliation: Division of Animal Model, Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

    X
  • Fumihiko Takeuchi,

    Affiliation: Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

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  • Masato Isono,

    Affiliation: Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

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  • Koichi Akiyama,

    Affiliation: Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

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  • Yukiko Shimizu,

    Affiliation: Division of Animal Model, Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

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  • Motohito Goto,

    Affiliation: Division of Animal Model, Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

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  • Yi-Qiang Liang,

    Affiliation: Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

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  • Ken Yamamoto,

    Affiliation: Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan

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  • Tomohiro Katsuya,

    Affiliations: Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan, Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan

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  • Akihiro Fujioka,

    Affiliation: Amagasaki Health Medical Foundation, Amagasaki Japan

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  • Keizo Ohnaka,

    Affiliation: Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

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  • Ryoichi Takayanagi,

    Affiliation: Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

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  • Toshio Ogihara,

    Affiliations: Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan, Morinomiya University of Medical Sciences, Osaka, Japan

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  • Yukio Yamori,

    Affiliation: Mukogawa Women’s University Institute for World Health Development, Mukogawa, Japan

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  • Norihiro Kato mail

    nokato@ri.ncgm.go.jp

    Affiliation: Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

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  • Published: November 16, 2012
  • DOI: 10.1371/journal.pone.0049055

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