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Open Access

Peer-reviewed

Research Article

Structures of SHV-1 β-Lactamase with Penem and Penam Sulfone Inhibitors That Form Cyclic Intermediates Stabilized by Carbonyl Conjugation

  • Wei Ke,

    Affiliation Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, United States of America

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  • Priyaranjan Pattanaik,

    Affiliation Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, United States of America

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  • Christopher R. Bethel,

    Affiliation Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, United States of America

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  • Anjaneyulu Sheri,

    Affiliation Department of Chemistry, Southern Methodist University, Dallas, Texas, United States of America

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  • John D. Buynak,

    Affiliation Department of Chemistry, Southern Methodist University, Dallas, Texas, United States of America

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  • Robert A. Bonomo,

    Affiliations Department of Medicine, Pharmacology, and Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, United States of America, Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, United States of America

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  • Focco van den Akker

    focco.vandenakker@case.edu

    Affiliation Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, United States of America

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