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Research Article

IL-12p40 Deficiency Leads to Uncontrolled Trypanosoma cruzi Dissemination in the Spinal Cord Resulting in Neuronal Death and Motor Dysfunction

  • André Luis Bombeiro mail,

    andrelb@icb.usp.br

    Affiliations: Department of Immunology, Biomedical Sciences Institute, University of São Paulo, São Paulo, São Paulo, Brazil, Neuroregeneration Center, Department of Neurology, University of São Paulo School of Medicine, São Paulo, São Paulo, Brazil

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  • Lígia Antunes Gonçalves,

    Affiliation: Instituto Gulbenkian de Ciência, Oeiras, Portugal

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  • Carlos Penha-Gonçalves,

    Affiliation: Instituto Gulbenkian de Ciência, Oeiras, Portugal

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  • Claudio Romero Farias Marinho,

    Affiliation: Department of Parasitology, Biomedical Sciences Institute, University of São Paulo, São Paulo, São Paulo, Brazil

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  • Maria Regina D’Império Lima,

    Affiliation: Department of Immunology, Biomedical Sciences Institute, University of São Paulo, São Paulo, São Paulo, Brazil

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  • Gerson Chadi,

    Affiliation: Neuroregeneration Center, Department of Neurology, University of São Paulo School of Medicine, São Paulo, São Paulo, Brazil

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  • José Maria Álvarez

    Affiliation: Department of Immunology, Biomedical Sciences Institute, University of São Paulo, São Paulo, São Paulo, Brazil

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  • Published: November 12, 2012
  • DOI: 10.1371/journal.pone.0049022

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