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Research Article

Chronic Temporal Lobe Epilepsy Is Associated with Enhanced Alzheimer-Like Neuropathology in 3×Tg-AD Mice

  • Xiao-Xin Yan mail,

    yanxiaoxin@csu.edu.cn (XXY); grose@siumed.edu (GMR); ppatrylo@siu.edu (PRP)

    Affiliation: Department of Anatomy and Neurobiology, Central South University Xiangya School of Medicine, Changsha, Hunan, China

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  • Yan Cai,

    Affiliations: Department of Anatomy and Neurobiology, Central South University Xiangya School of Medicine, Changsha, Hunan, China, Center for Integrated Research in Cognitive and Neural Sciences, Southern Illinois University Carbondale, Illinois, United States of America, Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois, United States of America

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  • Jarod Shelton,

    Affiliation: Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois, United States of America

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  • Si-Hao Deng,

    Affiliation: Department of Anatomy and Neurobiology, Central South University Xiangya School of Medicine, Changsha, Hunan, China

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  • Xue-Gang Luo,

    Affiliation: Department of Anatomy and Neurobiology, Central South University Xiangya School of Medicine, Changsha, Hunan, China

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  • Salvatore Oddo,

    Affiliation: Department of Physiology and The Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

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  • Frank M. LaFerla,

    Affiliation: Department of Neurobiology and Behavior, University of California Irvine, Irvine, California, United States of America

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  • Huaibin Cai,

    Affiliation: Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, United States of America

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  • Gregory M. Rose mail,

    yanxiaoxin@csu.edu.cn (XXY); grose@siumed.edu (GMR); ppatrylo@siu.edu (PRP)

    Affiliations: Center for Integrated Research in Cognitive and Neural Sciences, Southern Illinois University Carbondale, Illinois, United States of America, Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois, United States of America

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  • Peter R. Patrylo mail

    yanxiaoxin@csu.edu.cn (XXY); grose@siumed.edu (GMR); ppatrylo@siu.edu (PRP)

    Affiliations: Center for Integrated Research in Cognitive and Neural Sciences, Southern Illinois University Carbondale, Illinois, United States of America, Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois, United States of America

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  • Published: November 14, 2012
  • DOI: 10.1371/journal.pone.0048782

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