Fasudil Protects the Heart against Ischemia-Reperfusion Injury by Attenuating Endoplasmic Reticulum Stress and Modulating SERCA Activity: The Differential Role for PI3K/Akt and JAK2/STAT3 Signaling Pathways

Yapeng Li; Wei Zhu; Jianping Tao; Ping Xin; Mingya Liu; Jingbo Li; Meng Wei

doi:10.1371/journal.pone.0048115

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Research Article

Fasudil Protects the Heart against Ischemia-Reperfusion Injury by Attenuating Endoplasmic Reticulum Stress and Modulating SERCA Activity: The Differential Role for PI3K/Akt and JAK2/STAT3 Signaling Pathways

Yapeng Li ,

Contributed equally to this work with: Yapeng Li, Wei Zhu, Jianping Tao

Affiliation Division of Cardiology, Shanghai Sixth Hospital, Shanghai Jiao Tong University School of Medicine, State Key Discipline Division, Shanghai, People's of Republic of China
⨯
Wei Zhu ,

Contributed equally to this work with: Yapeng Li, Wei Zhu, Jianping Tao

* E-mail: weizhu65@yahoo.com (WZ); weim.sjtu6h@hotmail.com (MW)

Affiliation Division of Cardiology, Shanghai Sixth Hospital, Shanghai Jiao Tong University School of Medicine, State Key Discipline Division, Shanghai, People's of Republic of China
⨯
Jianping Tao ,

Contributed equally to this work with: Yapeng Li, Wei Zhu, Jianping Tao

Affiliation Division of Cardiology, Shanghai Sixth Hospital, Shanghai Jiao Tong University School of Medicine, State Key Discipline Division, Shanghai, People's of Republic of China
⨯
Ping Xin,

Affiliation Division of Cardiology, Shanghai Sixth Hospital, Shanghai Jiao Tong University School of Medicine, State Key Discipline Division, Shanghai, People's of Republic of China
⨯
Mingya Liu,

Affiliation Division of Cardiology, Shanghai Sixth Hospital, Shanghai Jiao Tong University School of Medicine, State Key Discipline Division, Shanghai, People's of Republic of China
⨯
Jingbo Li,

Affiliation Division of Cardiology, Shanghai Sixth Hospital, Shanghai Jiao Tong University School of Medicine, State Key Discipline Division, Shanghai, People's of Republic of China
⨯
Meng Wei

* E-mail: weizhu65@yahoo.com (WZ); weim.sjtu6h@hotmail.com (MW)

Affiliation Division of Cardiology, Shanghai Sixth Hospital, Shanghai Jiao Tong University School of Medicine, State Key Discipline Division, Shanghai, People's of Republic of China
⨯

Fasudil Protects the Heart against Ischemia-Reperfusion Injury by Attenuating Endoplasmic Reticulum Stress and Modulating SERCA Activity: The Differential Role for PI3K/Akt and JAK2/STAT3 Signaling Pathways

Yapeng Li,
Wei Zhu,
Jianping Tao,
Ping Xin,
Mingya Liu,
Jingbo Li,
Meng Wei

x

Published: October 31, 2012
https://doi.org/10.1371/journal.pone.0048115

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Reperfusion
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Stress signaling cascade
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Heart
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Apoptosis
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Reperfusion injury
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Endoplasmic reticulum
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Signal inhibition
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Phosphorylation
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