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Research Article

In Vivo Capsular Switch in Streptococcus pneumoniae – Analysis by Whole Genome Sequencing

  • Fen Z. Hu,

    Affiliations: Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology and Immunology, Drexel College of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Rory Eutsey,

    Affiliation: Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, Pennsylvania, United States of America

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  • Azad Ahmed,

    Affiliation: Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, Pennsylvania, United States of America

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  • Nelson Frazao,

    Affiliations: Laboratory of Molecular Genetics, Instituto de Tecnologia Química e Biológica Oeiras, Portugal, Laboratory of Microbiology and Infectious Diseases, Rockefeller University, New York, New York, United States of America

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  • Evan Powell,

    Affiliation: Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, Pennsylvania, United States of America

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  • N. Luisa Hiller,

    Affiliation: Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, Pennsylvania, United States of America

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  • Todd Hillman,

    Affiliation: Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, Pennsylvania, United States of America

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  • Farrel J. Buchinsky,

    Affiliation: Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, Pennsylvania, United States of America

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  • Robert Boissy,

    Affiliation: Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, Pennsylvania, United States of America

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  • Benjamin Janto,

    Affiliations: Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology and Immunology, Drexel College of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Jennifer Kress-Bennett,

    Affiliations: Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology and Immunology, Drexel College of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Mark Longwell,

    Affiliation: Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, Pennsylvania, United States of America

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  • Suzanne Ezzo,

    Affiliation: Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, Pennsylvania, United States of America

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  • J. Christopher Post,

    Affiliations: Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology and Immunology, Drexel College of Medicine, Pittsburgh, Pennsylvania, United States of America, Deparment of Otolaryngology Head and Neck Surgery, Drexel College of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Mirjana Nesin,

    Affiliation: Laboratory of Microbiology and Infectious Diseases, Rockefeller University, New York, New York, United States of America

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  • Alexander Tomasz,

    Affiliation: Laboratory of Microbiology and Infectious Diseases, Rockefeller University, New York, New York, United States of America

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  • Garth D. Ehrlich mail

    gehrlich@wpahs.org

    Affiliations: Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology and Immunology, Drexel College of Medicine, Pittsburgh, Pennsylvania, United States of America, Deparment of Otolaryngology Head and Neck Surgery, Drexel College of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Published: November 08, 2012
  • DOI: 10.1371/journal.pone.0047983

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