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Open Access

Peer-reviewed

Research Article

Epigenetic Disruption of the PIWI Pathway in Human Spermatogenic Disorders

  • Holger Heyn,

    Affiliation Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L’Hospitalet de Llobregat, Barcelona, Catalonia, Spain

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  • Humberto J. Ferreira ,

    Contributed equally to this work with: Humberto J. Ferreira, Lluís Bassas

    Affiliations Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L’Hospitalet de Llobregat, Barcelona, Catalonia, Spain, PhD Programme in Experimental Biology and Biomedicine, Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal

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  • Lluís Bassas ,

    Contributed equally to this work with: Humberto J. Ferreira, Lluís Bassas

    Affiliation Laboratory of Seminology and Embryology, Andrology Service-Fundació Puigvert, Barcelona, Catalonia, Spain

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  • Sandra Bonache,

    Current address: Oncogenetics Laboratory, University Hospital Vall d’Hebron, Barcelona, Catalonia, Spain

    Affiliation Human Molecular Genetics Group, Bellvitge Biomedical Research Institute (IDIBELL), 08908 L’Hospitalet de Llobregat, Barcelona, Catalonia, Spain

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  • Sergi Sayols,

    Affiliation Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L’Hospitalet de Llobregat, Barcelona, Catalonia, Spain

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  • Juan Sandoval,

    Affiliation Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L’Hospitalet de Llobregat, Barcelona, Catalonia, Spain

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  • Manel Esteller ,

    mesteller@idibell.cat

    These authors are joint senior authors of this work.

    Affiliations Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L’Hospitalet de Llobregat, Barcelona, Catalonia, Spain, Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain, Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain

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  • Sara Larriba

    These authors are joint senior authors of this work.

    Affiliation Human Molecular Genetics Group, Bellvitge Biomedical Research Institute (IDIBELL), 08908 L’Hospitalet de Llobregat, Barcelona, Catalonia, Spain

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