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Research Article

Age-Dependent Changes in the Sphingolipid Composition of Mouse CD4+ T Cell Membranes and Immune Synapses Implicate Glucosylceramides in Age-Related T Cell Dysfunction

  • Alberto Molano,

    Affiliation: Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, United States of America

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  • Zhaofeng Huang,

    Affiliation: Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, United States of America

    Current address: Zhongshan Medical School, Sun Yat-Sen University, Guangzhou, Guangdong, China

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  • Melissa G. Marko,

    Affiliation: Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, United States of America

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  • Angelo Azzi,

    Affiliation: Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, United States of America

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  • Dayong Wu,

    Affiliation: Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, United States of America

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  • Elaine Wang,

    Affiliation: The Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, United States of America

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  • Samuel L. Kelly,

    Affiliation: The Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, United States of America

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  • Alfred H. Merrill Jr,

    Affiliation: The Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, United States of America

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  • Stephen C. Bunnell mail,

    stephen.bunnell@tufts.edu (SCB); simin.meydani@tufts.edu (SNM)

    Affiliation: Department of Pathology, Sackler Graduate School of Biomedical Sciences, Tufts University, Boston, Massachusetts, United States of America

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  • Simin Nikbin Meydani mail

    stephen.bunnell@tufts.edu (SCB); simin.meydani@tufts.edu (SNM)

    Affiliations: Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, United States of America, Department of Pathology, Sackler Graduate School of Biomedical Sciences, Tufts University, Boston, Massachusetts, United States of America

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  • Published: October 26, 2012
  • DOI: 10.1371/journal.pone.0047650

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