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Research Article

Experimental and In Silico Modelling Analyses of the Gene Expression Pathway for Recombinant Antibody and By-Product Production in NS0 Cell Lines

  • Emma J. Mead mail,

    E.J.Mead@kent.ac.uk (EJM); C.M.Smales@kent.ac.uk (CMS); T.von-der-Haar@kent.ac.uk (TvdH)

    Affiliations: School of Biosciences, University of Kent, Canterbury, United Kingdom, Centre for Molecular Processing, University of Kent, Canterbury, United Kingdom

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  • Lesley M. Chiverton,

    Affiliations: School of Biosciences, University of Kent, Canterbury, United Kingdom, Centre for Molecular Processing, University of Kent, Canterbury, United Kingdom

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  • Sarah K. Spurgeon,

    Affiliations: School of Engineering and Digital Arts, University of Kent, Canterbury, United Kingdom, Centre for Molecular Processing, University of Kent, Canterbury, United Kingdom

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  • Elaine B. Martin,

    Affiliation: School of Chemical Engineering and Advanced Materials, Newcastle University, Newcastle, United Kingdom

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  • Gary A. Montague,

    Affiliation: School of Chemical Engineering and Advanced Materials, Newcastle University, Newcastle, United Kingdom

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  • C. Mark Smales mail,

    E.J.Mead@kent.ac.uk (EJM); C.M.Smales@kent.ac.uk (CMS); T.von-der-Haar@kent.ac.uk (TvdH)

    Affiliations: School of Biosciences, University of Kent, Canterbury, United Kingdom, Centre for Molecular Processing, University of Kent, Canterbury, United Kingdom

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  • Tobias von der Haar mail

    E.J.Mead@kent.ac.uk (EJM); C.M.Smales@kent.ac.uk (CMS); T.von-der-Haar@kent.ac.uk (TvdH)

    Affiliations: School of Biosciences, University of Kent, Canterbury, United Kingdom, Centre for Molecular Processing, University of Kent, Canterbury, United Kingdom

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  • Published: October 10, 2012
  • DOI: 10.1371/journal.pone.0047422

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