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Research Article

Hepatic FoxO1 Integrates Glucose Utilization and Lipid Synthesis through Regulation of Chrebp O-Glycosylation

  • Yukari Ido-Kitamura,

    Affiliations: Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan, Department of Internal Medicine, Fujisawa Shounandai Hospital, Fujisawa, Kanagawa, Japan

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  • Tsutomu Sasaki,

    Affiliation: Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan

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  • Masaki Kobayashi,

    Affiliation: Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan

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  • Hye-Jin Kim,

    Affiliation: Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan

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  • Yong-Soo Lee,

    Affiliation: Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan

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  • Osamu Kikuchi,

    Affiliation: Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan

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  • Hiromi Yokota-Hashimoto,

    Affiliation: Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan

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  • Katsumi Iizuka,

    Affiliation: Division of Molecule and Structure, Department of Diabetes and Endocrinology, Gifu University School of Medicine, Gifu, Gifu, Japan

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  • Domenico Accili,

    Affiliation: Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, United States of America

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  • Tadahiro Kitamura mail

    kitamura@gunma-u.ac.jp

    Affiliation: Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan

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  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0047231

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