Matrine Induces Apoptosis in Human Acute Myeloid Leukemia Cells via the Mitochondrial Pathway and Akt Inactivation

Shenghui Zhang; Yan Zhang; Yan Zhuang; Jiajie Wang; Jianqin Ye; Si Zhang; Jianbo Wu; Kang Yu; Yixiang Han

doi:10.1371/journal.pone.0046853

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Peer-reviewed

Research Article

Matrine Induces Apoptosis in Human Acute Myeloid Leukemia Cells via the Mitochondrial Pathway and Akt Inactivation

Shenghui Zhang,

Affiliations Key Laboratory of Molecular Medicine, Ministry of Education, and Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai, China, Laboratory of Internal Medicine, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China
⨯
Yan Zhang,

Affiliation Key Laboratory of Molecular Medicine, Ministry of Education, and Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai, China
⨯
Yan Zhuang,

Affiliation Department of Hematology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China
⨯
Jiajie Wang,

Affiliation Laboratory of Internal Medicine, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China
⨯
Jianqin Ye,

Affiliation Key Laboratory of Molecular Medicine, Ministry of Education, and Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai, China
⨯
Si Zhang,

Affiliation Key Laboratory of Molecular Medicine, Ministry of Education, and Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai, China
⨯
Jianbo Wu,

Affiliation Laboratory of Internal Medicine, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China
⨯
Kang Yu,

Affiliation Department of Hematology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China
⨯
Yixiang Han

* E-mail: yxhan2001@163.com

Affiliation Laboratory of Internal Medicine, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China
⨯

Matrine Induces Apoptosis in Human Acute Myeloid Leukemia Cells via the Mitochondrial Pathway and Akt Inactivation

Shenghui Zhang,
Yan Zhang,
Yan Zhuang,
Jiajie Wang,
Jianqin Ye,
Si Zhang,
Jianbo Wu,
Kang Yu,
Yixiang Han

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Published: October 8, 2012
https://doi.org/10.1371/journal.pone.0046853

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Apoptosis
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Cancer treatment
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Acute myeloid leukemia
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Mitochondria
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HL60 cells
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Leukemia
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Cancers and neoplasms
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Stem cell therapy
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