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Open Access

Peer-reviewed

Research Article

(−)-Epigallocatechin-3-Gallate Induces Non-Apoptotic Cell Death in Human Cancer Cells via ROS-Mediated Lysosomal Membrane Permeabilization

  • Yin Zhang,

    Affiliations Department of Toxicology, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

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  • Nai-Di Yang,

    Affiliation Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

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  • Fan Zhou,

    Affiliation Department of Toxicology, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China

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  • Ting Shen,

    Affiliation Department of Toxicology, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China

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  • Ting Duan,

    Affiliation Department of Toxicology, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China

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  • Jing Zhou,

    Affiliation Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

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  • Yin Shi,

    Affiliation Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

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  • Xin-Qiang Zhu ,

    zhuxq@zju.edu.cn (XQZ); han-ming_shen@nuhs.edu.sg (HMS)

    Affiliation Department of Toxicology, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China

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  • Han-Ming Shen

    zhuxq@zju.edu.cn (XQZ); han-ming_shen@nuhs.edu.sg (HMS)

    Affiliations Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore, NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore

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