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Open Access

Peer-reviewed

Research Article

Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells

  • Christophe J. De Saedeleer,

    Affiliation Pole of Pharmacology, Institut de Recherches Expérimentales et Cliniques (IREC), Université catholique de Louvain (UCL), Brussels, Belgium

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  • Tamara Copetti,

    Affiliation Pole of Pharmacology, Institut de Recherches Expérimentales et Cliniques (IREC), Université catholique de Louvain (UCL), Brussels, Belgium

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  • Paolo E. Porporato,

    Affiliation Pole of Pharmacology, Institut de Recherches Expérimentales et Cliniques (IREC), Université catholique de Louvain (UCL), Brussels, Belgium

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  • Julien Verrax,

    Affiliation Pole of Pharmacology, Institut de Recherches Expérimentales et Cliniques (IREC), Université catholique de Louvain (UCL), Brussels, Belgium

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  • Olivier Feron ,

    Contributed equally to this work with: Olivier Feron, Pierre Sonveaux

    Affiliation Pole of Pharmacology, Institut de Recherches Expérimentales et Cliniques (IREC), Université catholique de Louvain (UCL), Brussels, Belgium

    ⨯
  • Pierre Sonveaux

    Contributed equally to this work with: Olivier Feron, Pierre Sonveaux

    pierre.sonveaux@uclouvain.be

    Affiliation Pole of Pharmacology, Institut de Recherches Expérimentales et Cliniques (IREC), Université catholique de Louvain (UCL), Brussels, Belgium

    ⨯

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