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Research Article

Oxidative Stress Induced Inflammation Initiates Functional Decline of Tear Production

  • Yuichi Uchino,

    Affiliations: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan, Department of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan

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  • Tetsuya Kawakita mail,

    kawakita@a2.keio.jp

    Affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan

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  • Masaki Miyazawa,

    Affiliation: Department of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan

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  • Takamasa Ishii,

    Affiliation: Department of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan

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  • Hiromi Onouchi,

    Affiliation: Department of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan

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  • Kayo Yasuda,

    Affiliation: Department of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan

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  • Yoko Ogawa,

    Affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan

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  • Shigeto Shimmura,

    Affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan

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  • Naoaki Ishii,

    Affiliation: Department of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan

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  • Kazuo Tsubota

    Affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan

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  • Published: October 05, 2012
  • DOI: 10.1371/journal.pone.0045805

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