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Research Article

Characterization and Therapeutic Potential of Induced Pluripotent Stem Cell-Derived Cardiovascular Progenitor Cells

  • Ali Nsair equal contributor mail,

    equal contributor Contributed equally to this work with: Ali Nsair, Katja Schenke-Layland

    ansair@mednet.ucla.edu

    Affiliations: Department of Medicine and Physiology, Cardiovascular Research Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, The Edythe and Eli Broad Center for Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Katja Schenke-Layland equal contributor,

    equal contributor Contributed equally to this work with: Ali Nsair, Katja Schenke-Layland

    Affiliations: Department of Medicine and Physiology, Cardiovascular Research Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, Department of Cell and Tissue Engineering, Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Stuttgart, Germany, Department of Thoracic and Cardiovascular Surgery, Eberhard Karls University, Tübingen, Germany

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  • Ben Van Handel,

    Affiliations: Department of Molecular, Cell and Developmental Biology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, The Edythe and Eli Broad Center for Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Denis Evseenko,

    Affiliations: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, The Edythe and Eli Broad Center for Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Michael Kahn,

    Affiliation: Department of Biochemistry and Molecular Biology and Institute for Stem Cell and Regenerative Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Peng Zhao,

    Affiliation: Department of Medicine and Physiology, Cardiovascular Research Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Joseph Mendelis,

    Affiliation: Department of Medicine and Physiology, Cardiovascular Research Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Sanaz Heydarkhan,

    Affiliation: Department of Medicine and Physiology, Cardiovascular Research Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

    Current address: Department of Medicine and Physiology, Cardiovascular Research Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Obina Awaji,

    Affiliation: Department of Medicine and Physiology, Cardiovascular Research Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

    Current address: Department of Medicine and Physiology, Cardiovascular Research Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Miriam Vottler,

    Affiliations: Department of Cell and Tissue Engineering, Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Stuttgart, Germany, Department of Thoracic and Cardiovascular Surgery, Eberhard Karls University, Tübingen, Germany

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  • Susanne Geist,

    Affiliations: Department of Cell and Tissue Engineering, Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Stuttgart, Germany, Department of Thoracic and Cardiovascular Surgery, Eberhard Karls University, Tübingen, Germany

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  • Jennifer Chyu,

    Affiliation: Department of Medicine and Physiology, Cardiovascular Research Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Nuria Gago-Lopez,

    Affiliation: Department of Medicine and Physiology, Cardiovascular Research Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Gay M. Crooks,

    Affiliations: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, The Edythe and Eli Broad Center for Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Kathrin Plath,

    Affiliation: The Edythe and Eli Broad Center for Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Josh Goldhaber,

    Affiliation: Cedars-Sinai Heart Institute, Los Angeles, California, United States of America

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  • Hanna K. A. Mikkola,

    Affiliations: Department of Molecular, Cell and Developmental Biology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, The Edythe and Eli Broad Center for Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • W. Robb MacLellan

    Affiliation: Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, United States of America

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  • Published: October 09, 2012
  • DOI: 10.1371/journal.pone.0045603

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