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Research Article

A Comprehensive Strategy to Discover Inhibitors of the Translesion Synthesis DNA Polymerase κ

  • Kinrin Yamanaka,

    Affiliations: Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, Oregon, United States of America, Center for Research on Occupational and Environmental Toxicology, Oregon Health & Science University, Portland, Oregon, United States of America

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  • Dorjbal Dorjsuren,

    Affiliation: National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Robert L. Eoff,

    Affiliation: Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

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  • Martin Egli,

    Affiliation: Department of Biochemistry, Center in Molecular Toxicology and Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • David J. Maloney,

    Affiliation: National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Ajit Jadhav,

    Affiliation: National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Anton Simeonov,

    Affiliation: National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America

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  • R. Stephen Lloyd mail

    lloydst@ohsu.edu

    Affiliations: Center for Research on Occupational and Environmental Toxicology, Oregon Health & Science University, Portland, Oregon, United States of America, Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon, United States of America

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  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0045032

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