Chemical Chaperones Improve Protein Secretion and Rescue Mutant Factor VIII in Mice with Hemophilia A

• Stefanie D. Roth ,

  Contributed equally to this work with: Stefanie D. Roth, Jörg Schüttrumpf

  Affiliation Institute for Transfusion Medicine and Immune Hematology, Clinics of the Johann Wolfgang Goethe University, German Red Cross Blood Donor Service Baden-Wuerttemberg - Hessen, Frankfurt am Main, Hesse, Germany

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• Jörg Schüttrumpf ,

  Contributed equally to this work with: Stefanie D. Roth, Jörg Schüttrumpf

  * E-mail: joerg_schuettrumpf@biotest.de

  Current address: Biotest AG, Dreieich, Hesse, Germany

  Affiliations Institute for Transfusion Medicine and Immune Hematology, Clinics of the Johann Wolfgang Goethe University, German Red Cross Blood Donor Service Baden-Wuerttemberg - Hessen, Frankfurt am Main, Hesse, Germany, Biomedical Research Institute Georg-Speyer-Haus, Frankfurt am Main, Hesse, Germany

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• Peter Milanov,

  Affiliation Institute for Transfusion Medicine and Immune Hematology, Clinics of the Johann Wolfgang Goethe University, German Red Cross Blood Donor Service Baden-Wuerttemberg - Hessen, Frankfurt am Main, Hesse, Germany

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• Daniela Abriss,

  Affiliation Institute for Transfusion Medicine and Immune Hematology, Clinics of the Johann Wolfgang Goethe University, German Red Cross Blood Donor Service Baden-Wuerttemberg - Hessen, Frankfurt am Main, Hesse, Germany

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• Christopher Ungerer,

  Affiliation Institute for Transfusion Medicine and Immune Hematology, Clinics of the Johann Wolfgang Goethe University, German Red Cross Blood Donor Service Baden-Wuerttemberg - Hessen, Frankfurt am Main, Hesse, Germany

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• Patricia Quade-Lyssy,

  Affiliation Institute for Transfusion Medicine and Immune Hematology, Clinics of the Johann Wolfgang Goethe University, German Red Cross Blood Donor Service Baden-Wuerttemberg - Hessen, Frankfurt am Main, Hesse, Germany

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• Jeremy C. Simpson,

  Affiliation School of Biology and Environmental Science, University College Dublin, Dublin, Ireland

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• Rainer Pepperkok,

  Affiliation Cell Biology and Biophysics Department, European Molecular Biology Laboratory (EMBL), Heidelberg, Baden-Wuerttemberg, Germany

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• Erhard Seifried,

  Affiliation Institute for Transfusion Medicine and Immune Hematology, Clinics of the Johann Wolfgang Goethe University, German Red Cross Blood Donor Service Baden-Wuerttemberg - Hessen, Frankfurt am Main, Hesse, Germany

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• Torsten Tonn

  Current address: Institute for Transfusion Medicine, Medical Faculty Carl Gustav Carus Dresden, German Red Cross Blood Donor Service East, Dresden, Saxony, Germany

  Affiliation Institute for Transfusion Medicine and Immune Hematology, Clinics of the Johann Wolfgang Goethe University, German Red Cross Blood Donor Service Baden-Wuerttemberg - Hessen, Frankfurt am Main, Hesse, Germany

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