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Research Article

Periostin Directly and Indirectly Promotes Tumor Lymphangiogenesis of Head and Neck Cancer

  • Yasusei Kudo mail,

    yasusei@tokushima-u.ac.jp (YK); ttakata@hiroshima-u.ac.jp (TT)

    Affiliations: Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan, Department of Oral Molecular Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

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  • Shinji Iizuka,

    Affiliation: Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

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  • Maki Yoshida,

    Affiliation: Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

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  • Phuong Thao Nguyen,

    Affiliation: Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

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  • Samadarani B. S. M. Siriwardena,

    Affiliation: Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

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  • Takaaki Tsunematsu,

    Affiliation: Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

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  • Mariko Ohbayashi,

    Affiliation: Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

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  • Toshinori Ando,

    Affiliation: Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

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  • Daijiro Hatakeyama,

    Affiliation: Department of Oral and Maxillofacial Sciences, Gifu University Graduate School of Medicine, Gifu, Japan

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  • Toshiyuki Shibata,

    Affiliation: Department of Oral and Maxillofacial Sciences, Gifu University Graduate School of Medicine, Gifu, Japan

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  • Keiichi Koizumi,

    Affiliation: Department of Kampo Diagnostic, Institute of Natural Medicine, University of Toyama, Toyama, Japan

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  • Masahiro Maeda,

    Affiliation: Department of Research and Development, Immuno-Biological Laboratories, Co., Ltd., Fujioka-shi, Gunma, Japan

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  • Naozumi Ishimaru,

    Affiliation: Department of Oral Molecular Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

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  • Ikuko Ogawa,

    Affiliation: Center of Oral Clinical Examination, Hiroshima University Hospital, Hiroshima, Japan

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  • Takashi Takata mail

    yasusei@tokushima-u.ac.jp (YK); ttakata@hiroshima-u.ac.jp (TT)

    Affiliation: Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

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  • Published: August 30, 2012
  • DOI: 10.1371/journal.pone.0044488

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