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Open Access

Peer-reviewed

Research Article

Random Mutagenesis Reveals Residues of JAK2 Critical in Evading Inhibition by a Tyrosine Kinase Inhibitor

  • Michael R. Marit,

    Affiliations Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada, Campbell Family Cancer Research Institute, Ontario Cancer Institute, Toronto, Ontario, Canada

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  • Manprit Chohan,

    Affiliations Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada, Campbell Family Cancer Research Institute, Ontario Cancer Institute, Toronto, Ontario, Canada

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  • Natasha Matthew,

    Affiliation Campbell Family Cancer Research Institute, Ontario Cancer Institute, Toronto, Ontario, Canada

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  • Kai Huang,

    Affiliation Campbell Family Cancer Research Institute, Ontario Cancer Institute, Toronto, Ontario, Canada

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  • Douglas A. Kuntz,

    Affiliation Campbell Family Cancer Research Institute, Ontario Cancer Institute, Toronto, Ontario, Canada

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  • David R. Rose,

    Affiliations Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada, Campbell Family Cancer Research Institute, Ontario Cancer Institute, Toronto, Ontario, Canada, Department of Biology, University of Waterloo, Waterloo, Ontario, Canada

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  • Dwayne L. Barber

    dbarber@uhnres.utoronto.ca

    Affiliations Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada, Campbell Family Cancer Research Institute, Ontario Cancer Institute, Toronto, Ontario, Canada

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