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Research Article

FXR Controls the Tumor Suppressor NDRG2 and FXR Agonists Reduce Liver Tumor Growth and Metastasis in an Orthotopic Mouse Xenograft Model

  • Ulrich Deuschle mail,

    ulrich.deuschle@phenex-pharma.com

    Affiliation: Department of Research, Phenex Pharmaceuticals AG, Heidelberg, Germany

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  • Julia Schüler,

    Affiliation: Department of In Vivo Tumor Biology, Oncotest GmbH, Freiburg, Germany

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  • Andreas Schulz,

    Affiliation: Department of Research, Phenex Pharmaceuticals AG, Heidelberg, Germany

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  • Thomas Schlüter,

    Affiliation: Department of Research, Phenex Pharmaceuticals AG, Heidelberg, Germany

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  • Olaf Kinzel,

    Affiliation: Department of Research, Phenex Pharmaceuticals AG, Heidelberg, Germany

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  • Ulrich Abel,

    Affiliation: Department of Medicinal Chemistry, Merz Pharmaceuticals GmbH, Frankfurt, Germany

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  • Claus Kremoser

    Affiliation: Department of Research, Phenex Pharmaceuticals AG, Heidelberg, Germany

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  • Published: October 09, 2012
  • DOI: 10.1371/journal.pone.0043044

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