SA-4-1BBL Costimulation Inhibits Conversion of Conventional CD4+ T Cells into CD4+FoxP3+ T Regulatory Cells by Production of IFN-γ

Shravan Madireddi; Rich-Henry Schabowsky; Abhishek K. Srivastava; Rajesh K. Sharma; Esma S. Yolcu; Haval Shirwan

doi:10.1371/journal.pone.0042459

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Peer-reviewed

Research Article

SA-4-1BBL Costimulation Inhibits Conversion of Conventional CD4⁺ T Cells into CD4⁺FoxP3⁺ T Regulatory Cells by Production of IFN-γ

Shravan Madireddi,

Affiliation Institute for Cellular Therapeutics, Department of Microbiology and Immunology, and James Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America
⨯
Rich-Henry Schabowsky,

Affiliation Institute for Cellular Therapeutics, Department of Microbiology and Immunology, and James Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America
⨯
Abhishek K. Srivastava,

Affiliation Institute for Cellular Therapeutics, Department of Microbiology and Immunology, and James Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America
⨯
Rajesh K. Sharma,

Affiliation Institute for Cellular Therapeutics, Department of Microbiology and Immunology, and James Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America
⨯
Esma S. Yolcu ,

Contributed equally to this work with: Esma S. Yolcu, Haval Shirwan

* E-mail: haval.shirwan@louisville.edu (HS); esma.yolcu@louisville.edu (ESY)

Affiliation Institute for Cellular Therapeutics, Department of Microbiology and Immunology, and James Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America
⨯
Haval Shirwan

Contributed equally to this work with: Esma S. Yolcu, Haval Shirwan

* E-mail: haval.shirwan@louisville.edu (HS); esma.yolcu@louisville.edu (ESY)

Affiliation Institute for Cellular Therapeutics, Department of Microbiology and Immunology, and James Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America
⨯

SA-4-1BBL Costimulation Inhibits Conversion of Conventional CD4⁺ T Cells into CD4⁺FoxP3⁺ T Regulatory Cells by Production of IFN-γ

Shravan Madireddi,
Rich-Henry Schabowsky,
Abhishek K. Srivastava,
Rajesh K. Sharma,
Esma S. Yolcu,
Haval Shirwan

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Published: August 1, 2012
https://doi.org/10.1371/journal.pone.0042459

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T cells
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Malignant tumors
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Signal inhibition
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