The Effects of Simvastatin or Interferon-α on Infectivity of Human Norovirus Using a Gnotobiotic Pig Model for the Study of Antivirals

Kwonil Jung; Qiuhong Wang; Yunjeong Kim; Kelly Scheuer; Zhenwen Zhang; Quan Shen; Kyeong-Ok Chang; Linda J. Saif

doi:10.1371/journal.pone.0041619

Loading metrics

Open Access

Peer-reviewed

Research Article

The Effects of Simvastatin or Interferon-α on Infectivity of Human Norovirus Using a Gnotobiotic Pig Model for the Study of Antivirals

Kwonil Jung,

Affiliation Food Animal Health Research Program, Ohio Agricultural Research and Development Center, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, Ohio, United States of America
⨯
Qiuhong Wang,

Affiliation Food Animal Health Research Program, Ohio Agricultural Research and Development Center, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, Ohio, United States of America
⨯
Yunjeong Kim,

Affiliation Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, United States of America
⨯
Kelly Scheuer,

Affiliation Food Animal Health Research Program, Ohio Agricultural Research and Development Center, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, Ohio, United States of America
⨯
Zhenwen Zhang,

Affiliation Food Animal Health Research Program, Ohio Agricultural Research and Development Center, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, Ohio, United States of America
⨯
Quan Shen,

Affiliation Food Animal Health Research Program, Ohio Agricultural Research and Development Center, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, Ohio, United States of America
⨯
Kyeong-Ok Chang,

Affiliation Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, United States of America
⨯
Linda J. Saif

* E-mail: saif.2@osu.edu

Affiliation Food Animal Health Research Program, Ohio Agricultural Research and Development Center, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, Ohio, United States of America
⨯

The Effects of Simvastatin or Interferon-α on Infectivity of Human Norovirus Using a Gnotobiotic Pig Model for the Study of Antivirals

Kwonil Jung,
Qiuhong Wang,
Yunjeong Kim,
Kelly Scheuer,
Zhenwen Zhang,
Quan Shen,
Kyeong-Ok Chang,
Linda J. Saif

x

Published: July 23, 2012
https://doi.org/10.1371/journal.pone.0041619

Viewed

Cited

Saved

Discussed

Powered by Altmetric

Questions or concerns about usage data? Please let us know.

Print

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Swine
Is the Subject Area "Swine" applicable to this article?

Thanks for your feedback.
Pig models
Is the Subject Area "Pig models" applicable to this article?

Thanks for your feedback.
Cholesterol
Is the Subject Area "Cholesterol" applicable to this article?

Thanks for your feedback.
Gastrointestinal tract
Is the Subject Area "Gastrointestinal tract" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Statins
Is the Subject Area "Statins" applicable to this article?

Thanks for your feedback.
Antivirals
Is the Subject Area "Antivirals" applicable to this article?

Thanks for your feedback.
Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.