Evolution of Heterogeneity (I²) Estimates and Their 95% Confidence Intervals in Large Meta-Analyses

• Kristian Thorlund ,

  * E-mail: thorluk@mcmaster.ca

  Affiliations Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada, Copenhagen Trial Unit, Department 3344, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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• Georgina Imberger,

  Affiliation Copenhagen Trial Unit, Department 3344, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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• Bradley C. Johnston,

  Affiliations Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada, Department of Anaesthesia and Pain Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada

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• Michael Walsh,

  Affiliations Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada, Division of Nephrology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada

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• Tahany Awad,

  Affiliation Copenhagen Trial Unit, Department 3344, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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• Lehana Thabane,

  Affiliations Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada, Biostatistics Unit, Father Sean O'Sullivan Research Centre, St Joseph's Healthcare – Hamilton, Hamilton, Ontario, Canada

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• Christian Gluud,

  Affiliation Copenhagen Trial Unit, Department 3344, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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• P. J. Devereaux,

  Affiliations Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada, Public Health Research Institute, McMaster University, Hamilton, Ontario, Canada

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• Jørn Wetterslev

  Affiliation Copenhagen Trial Unit, Department 3344, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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