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Research Article

Development of Novel Single-Stranded Nucleic Acid Aptamers against the Pro-Angiogenic and Metastatic Enzyme Heparanase (HPSE1)

  • Suzanne C. Simmons,

    Affiliation: Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, Buckinghamshire, United Kingdom

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  • Edward A. McKenzie,

    Affiliation: Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, Metropolitan County of Greater Manchester, United Kingdom

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  • Lynda K. Harris,

    Affiliation: Maternal and Fetal Health Research Centre, University of Manchester, Manchester, Metropolitan County of Greater Manchester, United Kingdom

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  • John D. Aplin,

    Affiliation: Maternal and Fetal Health Research Centre, University of Manchester, Manchester, Metropolitan County of Greater Manchester, United Kingdom

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  • Paul E. Brenchley,

    Affiliation: Renal Research Group, University of Manchester, Manchester, Metropolitan County of Greater Manchester, United Kingdom

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  • Maria N. Velasco-Garcia,

    Affiliation: Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, Buckinghamshire, United Kingdom

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  • Sotiris Missailidis mail

    s.missailidis@open.ac.uk

    Affiliation: Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, Buckinghamshire, United Kingdom

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  • Published: June 15, 2012
  • DOI: 10.1371/journal.pone.0037938

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