Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype

• Alvar Agustí ,

  * E-mail: alvar.agusti@clinic.ub.es

  Affiliations Thorax Institute, Hospital Clinic, Institut d’investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona and Centro de investigación en red de enfermedades respiratorias (CIBERES), Barcelona, Spain, Fundación Investigación Sanitaria Illes Balears (FISIB), Palma de Mallorca, Spain

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• Lisa D. Edwards,

  Affiliation GlaxoSmithKline, Research Triangle Park, North Carolina, United States of America

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• Stephen I. Rennard,

  Affiliation University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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• William MacNee,

  Affiliation University of Edinburgh, Edinburgh, UK

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• Ruth Tal-Singer,

  Affiliation GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America

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• Bruce E. Miller,

  Affiliation GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America

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• Jørgen Vestbo,

  Affiliations Respiratory Section, Hvidovre Hospital/University of Copenhagen, Denmark, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK

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• David A. Lomas,

  Affiliation University of Cambridge, Cambridge, UK

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• Peter M. A. Calverley,

  Affiliation University of Liverpool, Liverpool, UK

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• Emiel Wouters,

  Affiliation University of Maastricht, Maastricht, The Netherlands

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• Courtney Crim,

  Affiliation GlaxoSmithKline, Research Triangle Park, North Carolina, United States of America

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• Julie C. Yates,

  Affiliation GlaxoSmithKline, Research Triangle Park, North Carolina, United States of America

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• Edwin K. Silverman,

  Affiliation Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Harvey O. Coxson,

  Affiliation University of British Columbia, Vancouver, Canada

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• Per Bakke,

  Affiliation University of Bergen, Bergen, Norway

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• Ruth J. Mayer,

  Affiliation GlaxoSmithKline, Research Triangle Park, North Carolina, United States of America

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• Bartolome Celli,

  Affiliation Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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•  [ ... ],
• for the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators
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