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Caspase Inhibition with XIAP as an Adjunct to AAV Vector Gene-Replacement Therapy: Improving Efficacy and Prolonging the Treatment Window

  • Jingyu Yao,

    Affiliation Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

  • Lin Jia,

    Affiliation Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

  • Naheed Khan,

    Affiliation Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

  • Qiong-Duan Zheng,

    Affiliation Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

  • Ashley Moncrief,

    Affiliation Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

  • William W. Hauswirth,

    Affiliation Department of Ophthalmology, University of Florida College of Medicine, Gainesville, Florida, United States of America

  • Debra A. Thompson,

    Affiliations Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

  • David N. Zacks

    davzacks@umich.edu

    Affiliation Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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