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Research Article

Loss of the Urothelial Differentiation Marker FOXA1 Is Associated with High Grade, Late Stage Bladder Cancer and Increased Tumor Proliferation

  • David J. DeGraff mail,

    david.degraff@vanderbilt.edu

    Affiliation: Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Peter E. Clark,

    Affiliation: Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Justin M. Cates,

    Affiliation: Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Hironobu Yamashita,

    Affiliation: Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Victoria L. Robinson,

    Affiliation: Department of Surgery, University of Chicago, Chicago, Illinois, United States of America

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  • Xiuping Yu,

    Affiliation: Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Mark E. Smolkin,

    Affiliation: Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, United States of America

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  • Sam S. Chang,

    Affiliation: Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Michael S. Cookson,

    Affiliation: Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Mary K. Herrick,

    Affiliation: Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Shahrokh F. Shariat,

    Affiliation: Department of Urology, Weill Cornell Medical College, New York, New York, United States of America

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  • Gary D. Steinberg,

    Affiliation: Department of Surgery, University of Chicago, Chicago, Illinois, United States of America

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  • Henry F. Frierson,

    Affiliation: Department of Pathology, University of Virginia, Charlottesville, Virginia, United States of America

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  • Xue-Ru Wu,

    Affiliation: Deparments of Urology and Pathology, New York University, New York, New York, United States of America

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  • Dan Theodorescu,

    Affiliation: University of Colorado Comprehensive Cancer Center, Aurora, Colorado, United States of America

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  • Robert J. Matusik

    Affiliations: Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Published: May 10, 2012
  • DOI: 10.1371/journal.pone.0036669

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