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Open Access

Peer-reviewed

Research Article

The CEA/CD3-Bispecific Antibody MEDI-565 (MT111) Binds a Nonlinear Epitope in the Full-Length but Not a Short Splice Variant of CEA

  • Li Peng ,

    Contributed equally to this work with: Li Peng, Michael D. Oberst

    Affiliation Department of Antibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of America

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  • Michael D. Oberst ,

    Contributed equally to this work with: Li Peng, Michael D. Oberst

    Affiliation Preclinical Oncology, MedImmune LLC, Gaithersburg, Maryland, United States of America

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  • Jiaqi Huang,

    Affiliation Translational Sciences, MedImmune LLC, Gaithersburg, Maryland, United States of America

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  • Philip Brohawn,

    Affiliation Translational Sciences, MedImmune LLC, Gaithersburg, Maryland, United States of America

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  • Chris Morehouse,

    Affiliation Translational Sciences, MedImmune LLC, Gaithersburg, Maryland, United States of America

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  • Kristen Lekstrom,

    Affiliation Department of Antibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of America

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  • Patrick A. Baeuerle,

    Affiliation Amgen Research (Munich) GmbH, Munich, Germany

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  • Herren Wu,

    Affiliation Department of Antibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of America

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  • Yihong Yao,

    Affiliation Translational Sciences, MedImmune LLC, Gaithersburg, Maryland, United States of America

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  • Steven R. Coats,

    Affiliation Department of Antibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of America

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  • William Dall’Acqua,

    Affiliation Department of Antibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of America

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  • Melissa Damschroder ,

    damschroderm@medimmune.com (MD); hammonds@medimmune.com (SH)

    Affiliation Department of Antibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of America

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  • Scott A. Hammond

    damschroderm@medimmune.com (MD); hammonds@medimmune.com (SH)

    Affiliation Preclinical Oncology, MedImmune LLC, Gaithersburg, Maryland, United States of America

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