Inflammation-Driven Reprogramming of CD4⁺Foxp3⁺ Regulatory T Cells into Pathogenic Th1/Th17 T Effectors Is Abrogated by mTOR Inhibition in vivo

• Ekaterina Yurchenko,

  Affiliation Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Quebec, Canada

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• Marina T. Shio,

  Affiliation Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Quebec, Canada

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• Tony C. Huang,

  Affiliation Department of Pharmacology, McGill University, Montreal, Quebec, Canada

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• Maria Da Silva Martins,

  Affiliation Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Quebec, Canada

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• Moshe Szyf,

  Affiliation Department of Pharmacology, McGill University, Montreal, Quebec, Canada

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• Megan K. Levings,

  Affiliation Child and Family Research Institute, Department of Surgery, University of British Columbia, Vancouver, British Colombia, Canada

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• Martin Olivier,

  Affiliations Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Quebec, Canada, Department of Pharmacology, McGill University, Montreal, Quebec, Canada

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• Ciriaco A. Piccirillo

  * E-mail: Ciro.piccirillo@mcgill.ca

  Affiliations Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Quebec, Canada, FOCIS Center of Excellence, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada

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