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Mapping of Gene Expression Reveals CYP27A1 as a Susceptibility Gene for Sporadic ALS

  • Frank P. Diekstra ,

    Contributed equally to this work with: Frank P. Diekstra, Christiaan G. J. Saris, Leonard H. van den Berg, Jan H. Veldink

    Affiliation Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

  • Christiaan G. J. Saris ,

    Contributed equally to this work with: Frank P. Diekstra, Christiaan G. J. Saris, Leonard H. van den Berg, Jan H. Veldink

    Affiliation Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

  • Wouter van Rheenen,

    Affiliation Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

  • Lude Franke,

    Affiliation Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands

  • Ritsert C. Jansen,

    Affiliations Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands, Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands

  • Michael A. van Es,

    Affiliation Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

  • Paul W. J. van Vught,

    Affiliation Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

  • Hylke M. Blauw,

    Affiliation Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

  • Ewout J. N. Groen,

    Affiliation Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

  • Steve Horvath,

    Affiliations Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biostatistics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

  • Karol Estrada,

    Affiliation Department of Epidemiology and Biostatistics, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands

  • Fernando Rivadeneira,

    Affiliation Department of Epidemiology and Biostatistics, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands

  • Albert Hofman,

    Affiliation Department of Epidemiology and Biostatistics, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands

  • Andre G. Uitterlinden,

    Affiliation Department of Epidemiology and Biostatistics, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands

  • Wim Robberecht,

    Affiliations Department of Neurology, University Hospital Leuven, University of Leuven, Leuven, Belgium, Laboratory for Neurobiology, Vesalius Research Centre, Flanders Institute for Biotechnology (VIB), Leuven, Belgium

  • Peter M. Andersen,

    Affiliation Department of Clinical Neuroscience, Umeå University, Umeå, Sweden

  • Judith Melki,

    Affiliation Department of Neuropediatrics, University of Paris, Bicetre Hospital, Paris, France

  • Vincent Meininger,

    Affiliation Department of Neurology, Université Pierre et Marie Curie, Hôpital de la Salpêtrière, Paris, France

  • Orla Hardiman,

    Affiliations Department of Neurology, Beaumont Hospital, Dublin, Ireland, Department of Neurology, Trinity College, Dublin, Ireland

  • John E. Landers,

    Affiliations Department of Neurology, University of Massachusetts School of Medicine, Worcester, Massachusetts, United States of America, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

  • Robert H. Brown Jr.,

    Affiliations Department of Neurology, University of Massachusetts School of Medicine, Worcester, Massachusetts, United States of America, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

  • Aleksey Shatunov,

    Affiliation Medical Research Council Centre for Neurodegeneration Research, King’s College London, Department of Clinical Neuroscience, Institute of Psychiatry, London, United Kingdom

  • Christopher E. Shaw,

    Affiliation Medical Research Council Centre for Neurodegeneration Research, King’s College London, Department of Clinical Neuroscience, Institute of Psychiatry, London, United Kingdom

  • P. Nigel Leigh,

    Affiliation Medical Research Council Centre for Neurodegeneration Research, King’s College London, Department of Clinical Neuroscience, Institute of Psychiatry, London, United Kingdom

  • Ammar Al-Chalabi,

    Affiliation Medical Research Council Centre for Neurodegeneration Research, King’s College London, Department of Clinical Neuroscience, Institute of Psychiatry, London, United Kingdom

  • Roel A. Ophoff,

    Affiliations Department of Medical Genetics, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands, Center for Neurobehavioral Genetics, University of California Los Angeles, Los Angeles, California, United States of America

  • Leonard H. van den Berg ,

    Contributed equally to this work with: Frank P. Diekstra, Christiaan G. J. Saris, Leonard H. van den Berg, Jan H. Veldink

    Affiliation Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

  •  [ ... ],
  • Jan H. Veldink

    Contributed equally to this work with: Frank P. Diekstra, Christiaan G. J. Saris, Leonard H. van den Berg, Jan H. Veldink

    j.h.veldink@umcutrecht.nl

    Affiliation Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

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